Regulatory T cell differentiation: cooperation saves the day.
نویسندگان
چکیده
MicroRNA are important regulators of CD4 T cell differentiation, altering the balance between the immunogenic and tolerogenic pathways. Studies in mice with microRNA-deficient T cells have revealed defects in differentiation into the regulatory T cell lineage; however, the individual microRNA responsible have remained elusive. A recent paper in The EMBO Journal uses a systematic screen to find a novel cooperative action between an inducible and a constitutive microRNA in aiding regulatory T cell induction.
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ورودعنوان ژورنال:
- The EMBO journal
دوره 34 9 شماره
صفحات -
تاریخ انتشار 2015